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The airport is located sixteen miles (26 km) northwest of the center of Santiago.
The fare to the city center will be about 16,000-18,000 Pesos ($30-$35) with a travel time of around 30 minutes. Fares are metered, but it is suggested that you negotiate the fee in advance.
Tour Express (56-2-671-7380 Spanish-only) buses leave the airport every 1/2 hour from 6:30 A.M. to 9 P.M., and meet passengers arriving on flights during the night. The buses go to the city terminal on Moneda Street, and from there it is a short taxi ride to most hotels. The fare is around 1,000 pesos ($1.75) and a the trip takes about 30 minutes. The bus leaves from just outside the arrivals area.
Avis, Budget, Chilean, Hertz, Dollar and other local rental firms are at the airport.
World Airport Information Main Page
Adapted from How to Get Out of the Airport